What You Need to Know About Breast Cancer

Breast Cancer is Everyone’s Business!

October is National Breast Cancer Awareness Month, so here's important information for both women and men from UIC Pharmacy.

About Breast Cancer

Breast cancer is the second most common cancer in US women.  According to the American Cancer Society, an estimated 230,480 new cases of invasive breast cancer were diagnosed in 2011.  The exact cause of breast cancer is unknown, but several factors have been linked with changes that cause normal breast cells to become cancer cells.  Some of these risk factors include:

·       Being female.

·       Older age.

·       BRCA1 or BRCA2 gene mutations.

·       Family history of breast cancer.

·       High breast density (less fat tissue in the breast).

·       History of radiation therapy.

Other possible risk factors include race or ethnic background, environmental factors, and lifestyle choices.  For example, more Caucasian women get breast cancer than African American women.  Use of birth control pills and getting your first period at an age younger than 12 years both slightly increase the risk of breast cancer.  Talk to your doctor about possible risk factors you may have and things you can do to decrease your risk.

To learn more about risk factors and the strength of the scientific evidence for each factor, go to:

http://ww5.komen.org/BreastCancer/BreastCancerRiskFactorsTable.html

For a list of questions you can ask your doctor about breast cancer, go to:

http://ww5.komen.org/BreastCancer/QuestionstoAsktheDoctorPDFDownloads.html

Breast Cancer in Younger Women

Although older women have a higher risk of breast cancer and make up most of the patients with breast cancer, younger women may also be at risk.  Of the 70,000 patients aged 15 to 39 years who are diagnosed with cancer each year, 15% have breast cancer.  Breast cancer  in younger patients tends to be more aggressive than in older women.  The most common cause of cancer-related death in women aged 15 to 54 years is breast cancer.  Rates of breast cancer in African American women under the age of 35 are twice the rate in Caucasian women of the same age. 

To learn more about breast cancer in younger women, go to:

http://www.youngsurvival.org/breast-cancer-in-young-women/learn/statistics-and-disparities/

Breast Cancer in Men

Although rare (less than 1% of all breast cancer cases), men can get breast cancer.  An estimated 2,140 men in the U.S. will develop breast cancer in 2011.  Most cases of breast cancer in men are found in patients aged 60 to 70 years.  Risk factors and survival rates are similar in men and women, but breast cancer in men is usually more advanced at diagnosis, possibly because screening in men is less common.

To find out more breast cancer in men, go to:

http://www.cancer.gov/cancertopics/pdq/treatment/malebreast/patient

What are Warning Signs for Breast Cancer?

The most common warning signs are changes in the look or feel of your breast or nipple and nipple discharge.  It is important to know how your breasts look and feel normally so that you can recognize any changes.  Normal breasts can be lumpy.  If lumps are felt throughout both sides of the breast, they are most likely normal breast tissue.  Lumps that are hard or feel different from the rest of the breast tissue need to be checked by a healthcare provider.  Nipple discharge may occur for reasons other than cancer (such as infection), and should be evaluated by a healthcare provider in all cases.

To learn more about warning signs for breast cancer, go to:

http://ww5.komen.org/Content.aspx?id=5236&terms=symptoms

What are the Current Recommendations for Breast Cancer Screening?

Currently, a mammogram is the most effective and reliable diagnostic tool for breast cancer.  Self-exams and breast exams performed by a doctor have not been shown to reduce the risk of dying from breast cancer; however, not all cancer cells can be found through mammograms.  Therefore, the combination of regular self-exams, breast exams performed by a doctor, and mammograms is the best option for screening.

Visit this website to learn how to perform a breast self-exam: http://ww5.komen.org/BreastCancer/DownloadBSECards.html

Current recommendations for mammography for average risk women differ among organizations, but screening should generally start at age 40 and be repeated every 1 to 2 years.  Breast exams performed by a doctor in average risk women should start at age 20 and be repeated every 3 years until age 40, then every year after age 40.  The State of Illinois offers free mammograms, breast exams, and other screening tests to eligible women. 

To find out more about free breast cancer screening in Illinois, go to:

http://cancerscreening.illinois.gov/index.htm

For breast cancer screening resources in other states, go to:

http://apps.nccd.cdc.gov/cancercontacts/nbccedp/contacts.asp

Choices to consider

Maintaining a healthy weight through exercise and diet and limiting alcohol consumption to less than one drink per day can lower your risk for breast cancer.  Choosing whole grain foods, eating 5 servings of fruits and vegetables every day, and eating less meat are also healthy lifestyle choices that can lower your chances of getting breast cancer.  Your doctor may be able to suggest other lifestyle changes that you can make based on your specific breast cancer risk factors.

Get Involved: Things You Can Do About Breast Cancer Right Now

·       Send an E-card to people you care about to raise awareness about mammograms.

http://www2c.cdc.gov/ecards/message/message.asp?cardid=198

·       Post links about breast cancer awareness on your Facebook or Twitter page.

·       Become a friend of the Susan G. Komen Breast cancer Foundation on Facebook.

http://www.facebook.com/susangkomenforthecure?ecid=vanityurl%3A8

·       Find local events and ways to help people with cancer through the American Cancer Society.

http://www.cancer.org/InYourArea/index

Soojin Jun

Doctor of Pharmacy Candidate 2013

UIC College of Pharmacy

Breast Cancer Awareness

Breast Cancer Awareness
By Amy St. George, PharmD Candidate 2011
University of Illinois at Chicago College of Pharmacy

UIC Pharmacy

Every year in October we celebrate National Breast Cancer Awareness Month (NBCAM). 1 The NBCAM organization has been a leader in promoting awareness of breast cancer, and in 2009 they celebrated 25 years of awareness, education, and empowerment. According to the Center for Disease Control (CDC), after non-melanoma skin cancer, breast cancer is the most common form of cancer in women.2 Breast cancer is the number one cause of cancer death in Hispanic women and the second most common cause of cancer death in white, African-American, Asian/Pacific Islander, and American Indian/Alaska Native women. The American Cancer Society estimates that in the United States in 2010 there will be about 207,090 new cases of invasive breast cancer in women, and about 54,010 new cases of carcinoma in situ.3 They also estimate that about 39,840 women will die from breast cancer.

The chance of a woman having invasive breast cancer some time during her life is about 1 in 8. Breast cancer does not just affect women; men can also get this devastating disease. According to the American Cancer Society, about 1,970 new cases of invasive breast cancer will be diagnosed in men, and about 390 men will die from breast cancer this year. The outlook for men with breast cancer was once thought to be worse than that for women, but recent studies have not found this to be true. In fact, men and women with the same stage of breast cancer have a fairly similar outlook for survival. Breast cancer death rates have been going down. This is probably the result of finding the cancer earlier and better treatment. Currently, there are more than 2.5 million breast cancer survivors in the United States.

Risk factors for breast cancer

There are many risk factors for breast cancer that you may be able to control to decrease the chance of developing breast cancer; however, there are also some factors that you are not able to control.5 Table 1 describes both controllable and non-controllable breast cancer risk factors.

Table 1. Risk factors for breast cancer.5

Risk factors you CAN control

• Weight and diet
• Exercise
• Alcohol consumption
• Smoking
• Use of hormone replacement therapy
• Recent oral contraceptive use
• Stress and anxiety

Risk factors you CAN’T control

• Gender
• Age
• Race
• Family/personal history of breast cancer
• Radiation therapy to the chest
• Exposure to estrogen (ages at menarche and menopause or environmental exposure)
• Pregnancy and breastfeeding
• Diethylstilbestrol exposure-an estrogen-like hormone given to women to prevent miscarriages; daughters born to women who took this medication during pregnancy may be at a higher risk for breast cancer.

Early detection through screening

Screening for breast cancer is crucial for early detection. The earlier that breast cancer is detected the easier it is to treat.2 There is no such thing as a “normal” breast and lumps can be a normal occurrence in some women due to menstruation, changes in weight, having had children, or changes in breast tissue associated with age.

When screening for breast cancer, there are 3 main tests that can be performed: a self breast exam, a clinical breast exam by a physician or nurse, and a mammogram.2 Scheduled mammogram screenings should be done every 1 to 2 years after the age of 40. Although clinical breast exams are not as effective as a mammogram at detecting breast cancer, they do provide some benefit in detecting changes in breast tissue. These exams should be done as part of a routine health examination for all women, starting in their 20s and 30s.3 Monthly self breast exams are also important for all women, starting in their 20s, to determine what is normal for each woman. If you have a strong family history of breast cancer (eg, mother or sister) or had chest radiation therapy at a young age, regular mammogram screenings may need to begin earlier, before 40 years of age.

Diagnosis and Treatment Options

If a diagnostic test is needed, several options are available: breast ultrasound, diagnostic mammogram, magnetic resonance imaging (MRI), or a biopsy. If a breast cancer diagnosis is made, a health care professional will diagnose the stage of cancer based on the spread of the cancer cells within the breast or to various parts of the body.2 Treatment of breast cancer is based on the stage and type of the breast cancer. Possible treatment options include surgery, chemotherapy, and radiation. There are 5 stages of breast cancer and some stages are divided into classes within the stage. The 5 stages are 0 to IV, with I to III having stage rankings of A, B, or C within the stage. Table 2 describes breast cancer stages; the earlier the stage of cancer at detection, the greater chances of successful treatment.4

Table 2. Breast cancer stages.4

Stage 0 Class None Description Abnormal cells in the lining of the breast (ductal) or in the lobules of the breast (lobular). Referred to as carcinoma in situ.

Stage 1 Class A Description Cancer has formed and the tumor is 20 mm or smaller and confined to the breast.

Stage 1 Class B Description Either a cluster of cancer cells (0.3 to 2 mm) found in the lymph nodes or a tumor 20 mm or less and a cluster of cells found in the lymph nodes.

Stage 2 Class A Description A large tumor (20 to 50 mm) hat has not spread to the lymph nodes or a tumor less than 20 mm that has spread to the lymph nodes.

Stage 2 Class B Description A large tumor (20 to 50 mm) that has spread to the lymph nodes or a tumor greater than 50 mm that has not spread to the axillary lymph nodes

Stage 3 Class A Description Cancer is found in the axillary lymph nodes or lymph nodes near the breastbone

Stage 3 Class B Description Any size tumor that spread to the chest wall or skin of the breast

Stage 3 Class C Description Any size tumor that spread to chest wall and lymph nodes above or below the collarbone

Stage 4 Class None Description Cancer that has spread to other organs of the body

How to be involved

Being involved in education and awareness for breast cancer should not stop at the end of October. There are many ways to get involved and help spread the word all year long. The NBCAM website (http://www.nbcam.org/help_promote_nbcam.cfm) lists ways to be involved in your community or workplace to promote awareness of breast cancer. More ways to contribute to breast cancer awareness and a search for a cure can be found at the Susan G. Komen for the Cure website (http://ww5.komen.org/MakeADifference/ImHeretoMakeaDifference.html?itc=emoentpnt:3). Get out, get involved, and support the thousands of people that are affected each year by breast cancer.

References

1. National Breast Cancer Awareness Month. NBCAM 25 years. http://nbcam.org/index.cfm. Accessed August 3rd, 2010.
2. Centers for Disease Control and Prevention. Breast Cancer. http://www.cdc.gov/cancer/breast/basic_info/index.htm. Accessed August 3rd, 2010.
3. American Cancer Society. Breast Cancer. http://www.cancer.org/Cancer/BreastCancer/index. Accessed August 3rd, 2010.
4. National Cancer Institute. Breast Cancer Treatment (PDQ). http://www.cancer.gov/cancertopics/pdq/treatment/breast/patient. Accessed August 3rd, 2010.
5. Breastcancer.org. Lowering Risk for Everyone. http://www.breastcancer.org/risk/everyone/. Accessed August 3rd, 2010.